DBA dedicated Faculty | SDA Bocconi School of Management - Top Business School in Europe SDA und Psoriasis
When compared SDA und Psoriasis life-threatening illnesses Psoriasis is a mild complaint, but if you consider how it disfigures appearance it is nevertheless very disturbing. It SDA und Psoriasis a disease of the skin that most SDA und Psoriasis appears as red and scaly patches on the scalp. Sometimes it spreads across the whole head. It brings with it an irritating itch and is very stressful to those affected.
Doctors continue to study the causes of this skin disorder. It seems as though it can be inherited but there is no way anyone can catch psoriasis from another person. Evidence suggests that it is linked to read article in the immune system. The most common type of psoriasis disfigures the body with patches of dry, red patches of skin. These patches are covered in silver-colored scales. Medical terminology calls these patches plaques.
Many times they appear on the SDA und Psoriasis but they can also appear on knees, the lower back and virtually anywhere else on the body. In quite a number of cases the plaques become very itchy or sore. In extreme cases psoriasis may reviewed Papaverin und Psoriasis Salbe Baili cracking SDA und Psoriasis bleeding of joints. Of all the types of psoriasis SDA und Psoriasis psoriasis is by far the most common.
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Do you want to advertise on Facty Health? Share on Facebook Share on Twitter. Unsightly Scaly Skin on Scalp The most common type of psoriasis disfigures the body with patches of dry, red patches of skin. Disclaimer This site offers information designed for educational purposes only. Featured Articles 10 Foods to Improve Pregnancy 10 Foods for a Healthy Liver 10 Acid Reflux Trigger Foods. Submit an idea Send us short note about your idea!
Topical Psoriasis Treatments - Relief for Dry, Flaking Skin | Flaking skin, Plaque and An SDA und Psoriasis
To receive news and publication updates for Dermatology Research and Practice, enter your email address in the box below. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Psoriasis is a common inflammatory and immune-mediated skin disease.
There is growing controversy as to whether cardiovascular risk is elevated in psoriasis. A number of studies suggest a high prevalence of cardiovascular risk factors as well as cardiovascular diseases in psoriasis patients.
The objective of this study was to estimate cardiovascular risk score in SDA und Psoriasis patients and the relation between cardiovascular risk and psoriasis features. Cardiovascular risk was assessed by CUORE project risk score built within the longitudinal study of the Italian CUORE project and suited to populations with a low rate of coronary heart disease. A case-control study in psoriasis outpatients and controls with skin diseases other than psoriasis was performed.
CUORE project risk score was higher in patients than controls versus. Compared to controls, psoriasis patients have higher risk of developing major cardiovascular events. Cardiovascular risk was not related to psoriasis characteristics. Increased focus on identifying cardiovascular risk factors see more initiation of preventive lifestyle changes or therapeutic interventions in patients with psoriasis is warranted.
Psoriasis is a common inflammatory, SDA und Psoriasis skin disease [ 1 ]. Although psoriasis can present at any age, it has two peak periods of onset: In addition to its cutaneous manifestations, psoriasis has been associated with inflammatory arthritis, depression, anger, anxiety, frustration, and considerable health-related quality of life impairment, which appear independent of objective disease severity [ 45 ].
Once symptoms occur, the disease is characterized by a chronic course; spontaneous, long-term remissions occur in a minority of patients. Clinical manifestations are heterogeneous, ranging from limited to very extensive disease [ 1 ]. The exact etiology of psoriasis is not entirely SDA und Psoriasis there is strong evidence that the interaction of multiple genetic, immunologic, and environmental factors contribute to its pathogenesis.
As the understanding of psoriasis has evolved, so has the perception of disease pathophysiology [ 17 ], characterized by increased T lymphocyte activity [ 6 ].
T-helper Th -1, Th, and Th cell populations are expanded and stimulated to release inflammatory cytokines SDA und Psoriasis. Accordingly, the inflammation that drives psoriatic pathology is systemic [ 1 ]; this concept carries important public-health implications and has prompted a growing body of research.
As a systemic inflammatory condition, psoriasis may be analogous to other inflammatory, immune disorders, such as systemic lupus erythematosus and rheumatoid arthritis. Since the risk of myocardial infarction and other cardiovascular diseases is firmly established in these specific disorders, attention has been focused on whether cardiovascular risk factors and cardiovascular diseases are increased SDA und Psoriasis patients with psoriasis [ 48 ].
Although, the initial link between psoriasis and coronary artery disease was suggested in the s [ 910 ], there is growing controversy as to whether cardiovascular risk is elevated in psoriasis.
A number of studies suggest a high prevalence of cardiovascular risk factors e. A major limitation of most of these studies is that they focus on highly selected psoriasis patients, such as those hospitalized for their disease and are therefore likely biased toward patient populations with more severe disease. This selection bias may be important since some SDA und Psoriasis indicate that the increased cardiovascular risk may be confined to patients with severe skin disease [ 6 ].
This is because most people who develop atherosclerotic cardiovascular disease have several risk factors which interact to SDA und Psoriasis their total risk.
It follows that there is a need for clinicians to be able to estimate total risk of cardiovascular disease [ 11 ]. In contrast to the general population and patients with SDA und Psoriasis, rheumatoid arthritis, and systemic lupus erythematosus, there are very few information about the estimation of cardiovascular risk by means of specific risk scores in psoriasis patients using predictive equations [ 12 ].
Recent studies have examined the risk of cardiovascular events in patients with psoriasis according to the Framingham cardiovascular risk prediction score and documented that a high proportion of patients with psoriasis SDA und Psoriasis at substantially increased risk and making them potential candidates for pharmacological cardiovascular primary prophylaxis [ 8 ]. The SDA und Psoriasis risk score is a tool to predict the absolute risk of major coronary and cerebrovascular events at 5 and 10 years in adults from SDA und Psoriasis to 74 years of age by stratifying patients into 3 risk categories: This score is appropriate for United States, Australia, and New Zealand populations [ 11 ].
However, it is known that the Framingham function-based risk charts SDA und Psoriasis tend to overestimate absolute risk in populations with a low rate of coronary heart disease, such as Italy and, sometimes, this SDA und Psoriasis may occur in countries with a high rate [ 13 ]. Moreover, SDA und Psoriasis studies applying Framingham risk function to data from Danish and German prospective studies have demonstrated that the Framingham risk function clearly overestimates coronary heart disease risk also in these populations [ 11 ].
The objective of the current study was to estimate cardiovascular risk score in psoriasis check this out and the relation between cardiovascular risk and psoriasis features in a real-world setting.
Continue reading observational case-control study was performed at the psoriasis outpatient clinic of Dermatology Department University of Palermo, Italyover a period of 1 year from January through December The control group was recruited from nonpsoriatic patients attending http://planetenbild.de/und-guttate-psoriasis-behandlungen.php same Dermatology Department and included patients with melanocytic naevi, cutaneous melanoma, nonmelanoma skin cancer, cutaneous infectious diseases, and other benign conditions.
Patients suffering from inflammatory skin conditions or autoimmune diseases were excluded from the control group. Informed consent was obtained from all patients prior to inclusion and confidentiality of personal data was warranted. The year cardiovascular risk was assessed using the CUORE project risk score built within the Italian CUORE project. It is a prospective fixed-cohort study, including cohorts from the north, the centre, and the south of Italy.
Sincethe project is listed among those of the National Centre for Disease SDA und Psoriasis and Control, Ministry of Health, Rome. The CUORE project risk score allows estimating the probability of experiencing a first cardiovascular event myocardial infarction, stroke over the next 10 years knowing the level of eight risk factors for cardiovascular disease: It is validated in patients 35 to 69 years of age and without previous SDA und Psoriasis cardiovascular accidents.
Mathematical functions, derived from longitudinal studies carried out on population groups followed up over time, are used to assess the risk score. Data were collected using the software cuore.
Information recorded were cigarette smoking, personal history of myocardial infarction, stroke, hospitalization for major cardiovascular events and medication use, and clinical type and duration of psoriasis. Risk factors were assessed by using standardized procedures.
Laboratory analyses considered for risk assessment were TC, HDL-C, and glycaemia. SDA und Psoriasis and controls blood pressure was assessed by trained technicians before their routine dermatologic followup at the Dermatology Department SDA und Psoriasis University of Palermo.
Blood pressure was measured twice on the right arm, using a mercury sphygmomanometer, with the participant sitting after resting for 5 minutes. Inclusion criteria for psoriasis patients were a diagnosis of psoriasis lasting at least SDA und Psoriasis year; absence of any clinical sign and symptom of articular involvement SDA und Psoriasis diagnosis of arthropathy; absence of any systemic treatment for psoriasis in the previous 3 months prior to clinical evaluation.
The severity of the psoriasis was measured by means of the Psoriasis Area and Severity Index PASIthe most commonly used tool to assess disease severity in patients with psoriasis in clinical trials.
It measures erythema, infiltration, scaling, and extent of involvement of the four body areas head, trunk, arms, and SDA und Psoriasis. The PASI scale ranges from 0 to Psoriasis is classified as mild if the PASI is below 10 and moderate to severe if it is 10 or above [ 1415 ].
Data management and statistical analysis SDA und Psoriasis carried out using WINKS SDA, version 7. The analysis was performed for the sample as a whole and for subgroups of patients classified according to disease severity SDA und Psoriasis or moderate to severe and type type I or type II psoriasis. The study included patients and controls. Disease severity was assessed according to the psoriasis area and severity index.
The mean PASI was range 4— Psoriasis duration was 1 to 54 years mean. The mean age of the nonpsoriatic group was years and 75 Mean age was similar in cases and controls. There were no significant differences in gender between the groups. Descriptive analyses of the demographic characteristics of SDA und Psoriasis and controls appear in Table 1. On the basis of SDA und Psoriasis CUORE project risk score, 87 In the low risk group, CUORE project risk score mean was higher in patients than controls versus.
Mean age of patients and controls with a low risk SDA und Psoriasis was similar. Evenly, in the intermediate SDA und Psoriasis group, patients had a higher CUORE project risk score mean than controls versus.
Mean age of patients and controls with an intermediate risk score was not significantly different. We did not observe controls with a high risk score. Patients with type II psoriasis had a higher CUORE SDA und Psoriasis risk score, but it could be because of a higher mean age. Indeed, SDA und Psoriasis project risk score mean was no not significantly different in all age groups in type I and II psoriasis Table 3.
There was no correlation between psoriasis severity and CUORE project risk SDA und Psoriasis Table 4. Psoriasis has been associated with an increased risk of metabolic syndrome and its components diabetes mellitus, hypertension, hyperlipidemia, obesity, and smoking.
Diagnosis of SDA und Psoriasis syndrome carries with it an increased risk of cardiovascular morbidity and mortality and has important public-health SDA und Psoriasis [ 16 ]. The majority of epidemiological studies SDA und Psoriasis the cardiovascular risk in psoriasis relied on Framingham risk score [ 19 — 22 SDA und Psoriasis and one assessed DORICA, SCORE, and REDIGOR risk score [ 12 ].
Framingham risk score is considered to overestimate cardiovascular risk in European countries with a lower incidence of cardiovascular events while DORICA, SCORE, and REDIGOR are more suited to Mediterranean populations [ 12 ]. In our series, the year CUORE project cardiovascular risk score was assessed to patients and controls. Consistent with previous research, this study found a greater cardiovascular risk score in psoriasis patients than controls.
However, we report a higher proportion of patients with moderate cardiovascular risk We posit that this was due to the overestimation of Framingham cardiovascular risk score in European populations.
According to previous research, we found that cardiovascular risk increases with age. There is growing controversy as to whether cardiovascular risk is elevated in patients with moderate to severe psoriasis or those who had an earlier age of disease onset.
Some published studies indicate that the increased cardiovascular risk may be confined to patients with severe SDA und Psoriasis disease [ 17 ]. However, studies that focused on patients hospitalized for psoriasis may not be generalizable to the broader population of patients with psoriasis because only a few patients with the most severe disease require hospitalization. Furthermore, patients hospitalized for any condition generally have higher rates of comorbidities, smoking, and alcohol use, which can increase the risk of death compared with individuals who are not hospitalized SDA und Psoriasis 18 ].
In our series, consisted of psoriasis outpatients, which reflect the complete disease spectrum, course, and severity, no relationship was found between disease severity and cardiovascular risk score. Moreover, there was no correlation between psoriasis type and cardiovascular risk; this relation was not evaluated in previous studies. In a previous study, no correlation between disease duration and Framingham risk score has been reported [ 19 ].
Our findings, although the number of psoriasis patients and controls are limited, demonstrate that cardiovascular risk is higher in psoriasis even when assessed by a risk score not previously used in psoriasis patients and more suited to Mediterranean populations.
The aim of cardiovascular disease risk charts is to be a simple diagnostic and easily usable support in the clinical practice of general practitioners and specialists.
They describe the disease risk in a population much better than using any single risk factor. Ten-year cardiovascular risk assessment can be the first step to implement preventive actions in primary care. Several studies [ 1219 — 22 ] and our findings demonstrate that cardiovascular diseases and their associated risk factors are more common in patients with check this out SDA und Psoriasis in the general population.
The cause of this elevated risk is unclear. Some authors suggest that the profound psychological impact of psoriasis may drive risky behaviours such as obesity SDA und Psoriasis smoking and SDA und Psoriasis directly increase cardiovascular risk [ 23 ].
Others have suggested that there may be some intrinsic associated risk: However, the SDA und Psoriasis of the association between psoriasis and cardiovascular disease is likely to be more complex and multifactorial [ 10 ]. New evidence has led to the hypothesis that psoriasis confers increased cardiovascular risk above and beyond traditional risk factors.
Psoriasis and atherosclerosis are chronic inflammatory diseases with a considerable overlap of inflammatory mechanisms [ 24 ]. Involvement of lymphocytes in psoriasis immunopathogenesis, linked to Th1 SDA und Psoriasis Th17 patterns of immunological response, is believed to lead to a proinflammatory state, which has been associated with an increased risk of cardiovascular disease [ 2025 ].
Recognizing the increased prevalence of cardiovascular disease, the National Psoriasis SDA und Psoriasis has issued a consensus statement that alerts providers that patients with psoriasis may represent an emerging high-cardiovascular risk population and thus patients with psoriasis should be screened for cardiovascular risk factors. This consensus statement further recommends that appropriate lifestyle and pharmacologic therapies should be prescribed for patients with psoriasis who are at increased risk for SDA und Psoriasis diseases [ 5 ].
Of note, it has recently been suggested that patients with psoriasis are inadequately screened and treated for coronary risk factors.
Underdiagnosis and undertreatment of coronary risk factors may contribute to the increased risk of cardiovascular disease in psoriasis patients [ 24 ]. It is wellestablished that psoriasis is associated with increased risk of cardiovascular disease and increased prevalence of cardiovascular risk factors.
Screening practices and treatment aimed at cardiovascular risk factors SDA und Psoriasis disease remain a challenge in clinical practice. Treatment guidelines on management of cardiovascular risk factors and further studies are needed to evaluate the clinical utility of psoriasis in cardiovascular risk prediction and investigate the impact of psoriasis treatment on cardiovascular outcomes. The authors declare that there is no conflict of interests regarding the publication of this paper.
Home Journals About Us. Dermatology Research and Practice. Indexed in Web of Science. Table of Contents Author Guidelines Submit a Manuscript. Subscribe to Table of Contents Alerts. Table of Contents Alerts. Abstract Full-Text PDF Full-Text HTML Full-Text ePUB Full-Text XML Linked References Citations to this Article How to Cite this Article Views 1, Citations 3 ePub 31 PDF Introduction SDA und Psoriasis is a common inflammatory, immune-mediated skin disease [ 1 ].
Materials and Methods An observational case-control study was performed at the psoriasis outpatient clinic of Dermatology Department University of Palermo, Italyover a period of 1 year from January through December Results The study included patients and controls. Descriptive analysis SDA und Psoriasis the demographic and clinical data of cases read more controls.
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Jackie Justice is a practicing Dermatology doctor in Morristown, TN.